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T H U R S D A Y -F R ID A Y

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Department of Epidemiology and Biostatistics

University of California, San Francisco School of Medicine

6TH ANNUAL

OSTEOPOROSIS

NEW INSIGHTS IN RESEARCH, DIAGNOSIS,

AND CLINICAL CARE

C O U R S E D I R E C TO R

Dennis M. Black, PhD

Professor of Epidemiology and Biostatistics University of California, San Francisco

C O U R S E C O - C H A I R

Ann V. Schwartz, PhD

Associate Professor of Epidemiology and Biostatistics University of California, San Francisco Fairmont Hotel

San Francisco, California

University of California San Francisco

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Presented by the Department of Epidemiology

and Biostatistics of the University of California,

San Francisco School of Medicine, this 2-day

course features an expert faculty that will

discuss the epidemiology, pathophysiology,

diagnosis and treatment of osteoporosis.

Specific topics will include the cell biology of

osteoporosis, bone biomechanics, endocrine

and nutrition aspects of osteoporosis, and

advances in skeletal imaging, such as CT and

MRI scanning.

The course will also critically review current

treatment options and preview new treatments

under study. There will be an emphasis on

recent developments and current controversies

in the etiology, diagnosis and management of

osteoporosis.

TARGET AUDIENCE

The course is designed for physicians and other

professionals in health research or clinical care who

would find additional scientific background in the

disease helpful, including those specifically involved in

osteoporosis such as clinical trial managers, statisticians,

physical therapists, and radiologic technologists.

This year the conference will place more focus on the

latest clinical updates on diagnosis and treatments.

No prior clinical or scientific training in osteoporosis

is required.

An attendee completing this course should be able to:

• Incorporate the use of bone mineral density and the

new WHO risk-based guidelines to diagnose

osteoporosis;

• Recognize the basic epidemiology of osteoporosis

and risk factors for fractures;

• Identify underlying cellular mechanisms for

maintenance of bone strength;

• Discuss the advantages and disadvantages of a

variety of therapies approved for the treatment

and prevention of osteoporosis;

• Provide patients health education on the role of

calcium, other nutritional factors, and exercise in

the prevention of osteoporosis;

• Utilize current guidelines in the treatment and

screening of osteoporosis.

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Fairmont Hotel

San Francisco, California

ACCREDITATION

The University of California, San Francisco School of Medicine (UCSF) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. UCSF designates this educational activity for a maximum of 12.5AMA PRA Category 1 Credit(s)TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

This CME activity meets the requirements under California Assembly Bill 1195, continuing education and cultural and linguistic competency. Nurses:

For the purpose of

recertification, the American Nurses Credentialing Center acceptsAMA PRA Category 1 Credit™issued by organizations accredited by the ACCME.

Pharmacists: The California Board of Pharmacy accepts as continuing professional education those courses that meet the standard of relevance to pharmacy practice and have been approved forAMA PRA Category 1 Credit™.

Family Physicians: Application for CME credit has been filed with the American Academy of Family Physicians.Determination of credit is pending. Geriatric Medicine: The approved credits shown above include 12.5 credits toward meeting the

requirement under California Assembly Bill 1820, Geriatric Medicine.

6TH ANNUAL

OSTEOPOROSIS

NEW INSIGHTS IN RESEARCH, DIAGNOSIS,

AND CLINICAL CARE

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THURSDAY, JULY 16, 2009

8:00 am Registration and Continental Breakfast

MORNING MODERATOR: DENNIS M. BLACK, PHD

Bone Biology and Strength

8:30 Bone Structure and Function and the Bone Dolores M. Shoback, MD Remodeling Cycle

9:10 Q&A

9:20 Beyond BMD: Bone Quality and Bone Strength Mary L. Bouxsein, PhD 9:55 Q&A

Fractures and Their Epidemiology

10:00 Epidemiology and Risk Factors for Fracture Mary L. Bouxsein, PhD 10:30 Q&A

10:35 Break

Tools of Risk Assessment and Diagnosis

10:55 Osteoporosis Diagnosis: BMD, Bone Quality, Dennis M. Black, PhD and Biochemical Markers

11:25 Q&A

11:35 Case Studies of Interpretation of BMD Scans Deborah E. Sellmeyer, MD 12:05 pm Q&A

12:10 Lunch (on your own)

AFTERNOON MODERATOR: MARY L. BOUXSEIN, PHD

Tools of Risk Assessment and Diagnosiscontinued

1:40 Special Issues in the Diagnosis of Men Peggy M. Cawthon, PhD, MPH 2:05 Q&A

2:10 Secondary Causes of Osteoporosis and Diana M. Antoniucci, MD Clinical Evaluation

2:35 Q&A 2:40 Break

Special Topics in Osteoporosis

3:00 Bad to the Bones: Corticosteroids and Jonathan Graf, MD Other Medications

3:40 Q&A

3:45 Osteoporosis in Children: What's New? Laura K. Bachrach, MD 4:30 Q&A

4:40 pm Adjourn

FRIDAY, JULY 17, 2009

8:00 am Continental Breakfast

MORNING MODERATOR: DEBORAH E. SELLMEYER, MD

Special Topics in Osteoporosis (continued)

8:30 Diabetes, TZDs and Fracture Ann V. Schwartz, PhD 8:45 Q&A

8:50 Vertebroplasty and Kyphoplasty as Treatments Douglas C. Bauer, MD for Vertebral Fracture

9:10 Q&A

Treatment and Prevention: Non-Pharmacologic Interventions

9:15 Nutrition: Protein, Salt, and Other Nutrients Deborah E. Sellmeyer, MD 9:45 Q&A

9:50 Vitamin D and Calcium: Role in Prevention Deborah E. Sellmeyer, MD and Treatment of Fractures and Falls

10:20 Q&A

10:25 Break

10:45 Physical Activity Wendy Katzman, PT, DPTSc

11:05 Q&A

11:10 Fall Prevention and Hip Protectors Ann V. Schwartz, PhD, MPH 11:25 Q&A

Treatment and Prevention: Non-Pharmacologic Interventions

11:30 Estrogen, SERMS Steven T. Harris, MD, FACP

6TH ANNUAL

OSTEOPOROSIS

NEW INSIGHTS IN RESEARCH, DIAGNOSIS, AND

CLINICAL CARE

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general info

GENERAL INFORMATION

Pre-registration is preferred to ensure that registrants receive a syllabus and CME Certificate at the course. Advanced registration closes one (1) business day prior to start of course. On site registration fees, if applicable, will be applied after this date.

REGISTRATION INFORMATION

Tuition: $345 Physicians

$275 Nurses/ Pharmacists/ Allied Health Professionals/ Residents/Fellows Payment may be made by Visa, MasterCard, AmEx or check.

REGISTER VIA:

Online: www.cme.ucsf.edu

Mail: Complete course registration form and send with payment to: UCSF Office of CME P.O. Box 45368 San Francisco, CA 94145-0368

Fax: Fax completed registration form to: (415) 502-1795 (be sure to include your credit card number)

On-Site Registration: Generally we are able to accommodate on-site registration at our courses. To register by phone or to inquire about registration status, please call UCSF’s CME Registration Office at (415) 476-5808. Please check our website for up-to-date information on the course: www.cme.ucsf.edu. Please check our website for up-to-date information on the course: www.cme.ucsf.edu

REFUND POLICY

Cancellations received in writing before the first day of the course will be refunded, less a $75 administrative fee. No refunds will be made on cancellations received after that date.

CONFERENCE LOCATION

FAIRMONT HOTEL, San Francisco, California A block of guestrooms has been reserved at the special UCSF conference rate of $249/night. You are urged to make your reservations early. The cut off date is June 12, 2009, or until the group room block is filled. After this date, rooms will be provided on a space-available basis only. If you prefer to phone in your reservation, please identify yourself as a member of this conference to receive the special rate. To make hotel reservations on-line, go to:

https://resweb.passkey.com/go/osteoporosis. If you prefer to telephone in your reservation, call (800) 441-1414 and identify yourself as a member of this UCSF conference to receive the special rate. By staying at the host hotel, you help UCSF meet its contractual obligations and keep registration fees reasonable.

RENTAL CAR

Hertz is offering special rates for participants of this conference; simply call (800) 654-2240 and refer to identification number #03BW0128, or call your travel agent. You may also make reservations at www.Hertz.com. Advance reservations are recommended.

AIR TRANSPORTATION

Special arrangements have been made with Montgomery Travel Simply call (800) 391-2287 8:30-5:30pm PST or complete the form on the UCSF web page at www.montgomerytravel.com. In addition to offering lower rates than published airfares, ticketed passengers may take advantage of the after hours emergency service. There is a $40 service fee. UCSF has negotiated special fares with American and United Airlines for our course attendees. You may use the following tour codes to book on your own:

American (800) 433-1790 code: 15273 United (800) 521-4041 code: 510CF Fairmont Hotel

San Francisco, California

FRIDAY, JULY 17, 2009

(continued)

11:50 Q&A

12:05 pm Bisphosphonates Dennis M. Black, PhD

12:20 Q&A

12:30 Lunch (on your own)

AFTERNOON MODERATOR: ANN V. SCHWARTZ, PHD

Treatment and Prevention: Non-Pharmacologic Interventionscontinued

1:50 Anabolic Agents and their Combination with Dennis M. Black, PhD Anti-Resorptives

2:15 Q&A

2:20 New Treatments on the Horizon Steven R. Commings, MD, FACP 2:40 Q&A

2:45 Break

Clinical Issues, Choices, and Dilemmas in Osteoporosis Therapy

3:05 An Overview of Treatment Options: Dolores M. Shoback, MD Tailoring Them to Individual Patients

3:30 Q&A

3:35 Monitoring of Treatment in Osteoporosis: Douglas C. Bauer, MD BMD, Bone Markers, or None of the Above

3:55 Q&A

4:00 Case Study of an Older Post-Menopausal Woman Douglas C. Bauer, MD

4:15 Case Study of an Older Man Steven R. Cummings, MD, FACP 4:30 Case Study of a Pre-Menopausal Woman Diana M. Antoniucci, MD 4:45 Case Study of an Early Post-Menopausal Woman Steven T. Harris, MD, FACP 5:00 pm Adjourn/Evaluations/Certificates

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F o r m o re in fo rm a ti o n o r to re g is te r o n li n e v is it o u r w e b s it e a t w w w .c m e .u c s f. e d u .Y o u m a y a ls o re a c h u s b y c a ll in g th e O ff ic e o f C M E a t (4 1 5 ) 4 7 6 -4 2 5 1 o r e m a il in g in fo @ o c m e .u c s f. e d u . 0569 Univ ersity of Calif or nia, San F rancisco Office of Contin uing Medical Education UCSF Bo x 0742 San F rancisco , CA 94143-0742 Nor thern Calif ornia Bone and Mineral Symposium No v ember 6-7, 2009 Montere y, Calif or nia Inf ectious Diseases in Clinical Practice F ebr uar y 14-19, 2010 Big Island, Ha w aii Primar y Care Medicine: Update 2010 Apr il 4-9, 2010 Maui, Ha w aii COURSE CHAIR Dennis M. Black, PhD Professor of Epidemiology and Biostatistics University of California, San Francisco COURSE CO-CHAIR Ann V. Schwartz, PhD, MPH Associate Professor of Epidemiology and Biostatistics University of California, San Francisco

GUEST FACULTY

Laura K. Bachrach, MD Professor of Pediatrics Stanford University School of Medicine; Stanford, California Mary L. Bouxsein, PhD Assistant Professor, Department of Orthopedic Surgery

Harvard Medical School, Boston, MA

Peggy M. Cawthon, PhD, MPH Associate Scientist

San Francisco Coordinating Center; California Pacific Medical Center Research Institute San Francisco, California Steven R. Cummings, MD, FACP Sr. Scientist and Director of Clinical Research

CPMC Research Institute San Francisco Coordinating Center; San Francisco, California Deborah E. Sellmeyer, MD Associate Professor of Medicine, Director Johns Hopkins

Metabolic Bone Center Baltimore, Maryland

COURSE FACULTY

(University of California, San Francisco)

Diana M. Antoniucci, MD Assistant Professor of Medicine, Division of Endocrinology Douglas C. Bauer, MD Professor of Medicine and Epidemiology and Biostatistics Jonathan Graf, MD

Assistant Adjunct Professor of Medicine; Division of Rheumatology, San Francisco General Hospital

Steven T. Harris, MD, FACP Clinical Professor of Medicine Wendy Katzman, PT, DPTSc Assistant Clinical Professor of Physical Therapy & Rehabilitation Science

Dolores M. Shoback, MD Professor of Medicine, UCSF Endocrine Research Unit San Francisco VA Medical Center

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Dr. Mr. Mrs. Ms.

_________________________________________________________________

Last Name First M.I.

_________________________________________________________________

Degree Specialty

_________________________________________________________________

Address

_________________________________________________________________

City State Zip

_________________________________________________________________

Daytime Phone Fax

_________________________________________________________________

Email

_________________________________________________________________

Address Label Code Letter (see address label: example, A, B, C, D, etc.)

Would you like to be on our priority email list? Yes No

Date of birth to be used as OCME registrant number: ___ ___ /___ ___ /

X X

Month Day

Please indicate if you have any special needs:_____________________________________ Registration Fees(receipt/Confirmation will be mailed within two to four weeks):

$345 Physicians

$275 Nurses/Pharmacist/Allied Health Professionals /Residents/Fellows Make checks payable to UC Regents

Please charge my credit card: Visa MasterCard AmEx for $ _________________________

_________________________________________________|________/_______

Card # Expiration date

___________________________________|______________________________

Name on Card (Please Print) Authorized Signature

Refund Policy: Cancellations received in writing before the first day of the course will be refunded, less a $75 administrative fee. No refunds will be made on cancellations received after that date.

Please check our website for up to date information on the course: www.cme.ucsf.edu. 6TH ANNUAL

OSTEOPOROSIS: NEW INSIGHTS IN RESEARCH,

DIAGNOSIS, AND CLINICAL CARE

July 16-17, 2009

Fairmont Hotel • San Francisco, California

MEP10001

Cable Car Line 101 101 101 80 280 Jefferson St Beach St North Point St Francisco St Francisco St Chestnut St Lombard St Greenwich St Filbert St Chestnut St Lombard St Greenwich St Filbert St Union St Union St Green St Green St Vallejo St Pacific St Jackson St Washington St Clay St Sacramento St Sacramento St California St California St Vallejo St Pacific St Jackson St Washington St Clay St Sacramento St California St Pine St Bush St Pine St Bush St Sutter St Post St Geary St Greenwich St Chestnut St Filbert St Union St Green St Vallejo St Pacific St Jackson St Washington St Clay St Pine St Bush St Sutter St Post St Post St Geary St O’Farrell St Ellis St Ellis St O’Farrell St O’Farrell St Ellis St Eddy St Turk St Golden Gate S t McAllister St Eddy St Turk St Golden Gate S t McAllister St Grove St Hayes St Page St Page St Grove St Hayes St Fulton St Fulton St Fulton St F ron t S t D av is S t D ru m m S t Ste ua rt St Spe ar St M ain St B eale St Frem ont S t 2n d St 5th St 6th S t 7th S t 8th St 9th St 10th St 11th St 12th St 12th S t Mis sion St Mis sion S t How ard St Har rison St Har rison St Bry ant S t Sou th P ark Bra nnan St Tow nsen d S t King St Bry ant S t Bra nnan St Tow nsen d S t King St Chann el S t N ew M on tgom ery S t B a tte ry St S an s om e S t Ba tte ry S t Sa n so m e St M on tgom e ry S t M o n tgo m e ry St M o n tg om e ry St K ea rny St K ea rny St C olum bu s Av G ran t A v G ran t A v K e a rn y S t G ran t A v P ow e ll S t M as on St M as o n St T a ylo r S t T ay lo r S t Po w e ll S t M as on St T ay lo r S t J on es St L e av en w o rth St H yd e S t J on e s St L ea ve n w o rth St H y de St Jo ne s St L ea v e n w o rth St H yd e S t L a rk in St P o lk St L a rk in St P o lk St L a rk in St P o lk S t S tock to n S t P ow e ll S t S toc k ton St S tock to n S t O c ta via St La gu n a S t O cta v ia St L a gu na St B uc h an an St B u c ha n a n S t B u c ha na n S t W e bs te r S t W e bs te r S t F illm o re S t F illm o re S t O c tav ia St L a g un a S t L a gu na St W e bs te r S t F illm o re S t W e bs te r S t F illm o re S t S te ine r S t S te in e r S t P ie rc e S t S c o tt St P ie rce St V a n N es s A v G o ug h S t Pete r Yor kewy Starr King Wy Bay St North Pt Beach St McCoppin St Mis sion St Haight St Waller St Hermann St V a le n c ia S t B u c ha n an S t Berry St Bay St Bay St Broadway Broadway Broadway V an Ne ss Av V a n Ne s s Av S ou th Va n N es s A v F ran k lin S t G ou g h St F ra nk lin St F ran k lin St G o ug h St TheE m barc ad ero TheE m barc ad ero Geary Expwy Fols om S t Fols om St 3rd S t 3rd S t Howar d St 1s t St Mar ket S t Mar ket S t Mar ket S t Mar ket S t Fell St Oak St Fell St Oak St Lombard St M arin a Bl 4th St 4th St Berry St NORTH BEACH PLAYGROUND MICHELANGELO PLAYGROUND WASHINGTON SQUARE WALTON PARK GEORGE R. MOSCONE RECREATION CENTER LAFAYETTE PARK AQUATIC PARK ALAMO SQUARE SAN FRANCISCO BAY MIS SIO N C REE K GHIRARDELLI SQUARE THE CANNERY CROOKED STREET FORT MASON CENTER PIER 39 BROADWAY PIER (Pedestrian) JUSTIN HERMAN PLAZA PORTSMOUTH SQUARE MOSCONE CONVENTION CENTER NORTH & SOUTH

SF CITY HALL CIVIC AUDITORIUM BROOKS HALL MAIN LIBRARY CENTER FOR THE ARTS AT YERBA BUENA GARDENS UNION SQUARE UC EXTENTION SF ART INSTITUTE UNDERWATER WORLD AQUARIUM YOUTH HOSTEL MARITIME MUSEUM FT. MASON VISITOR CENTER COIT TOWER STS PETER AND PAUL TRANSAMERICA PYRAMID BLDG. GRACE CATHEDRAL MASONIC AUDITORIUM TRANSBAY TERMINAL FERRY BUILDING RINCON CENTER WORLD TRADE CTR. EMBARCADERO SHOPPING CENTER GOLDEN GATE UNIV. SF MUSEUM OF MODERN ART CALTRAIN DEPOT SF SHOPPING CENTRE CROCKER GALLERIA OLD MINT OF SF OPERA HOUSE WAR MEM. THEATER ST. MARY'S CATHEDRAL JAPANESE CULTURAL & TRADE CENTER PAINTED LADIES (victorian houses) VAN NESS STATION CIVIC CENTER STATION POWELL ST. STATION MONTGOMERY ST. STATION EMBARCADERO STATION OCTAGON HOUSE LEVI'S PLAZA BANK OF AMERICA BLDG. FISHERMAN'S WHARF TELEGRAPH HILL NORTH BEACH FINANCIAL DISTRICT CHINATOWN RUSSIAN HILL COW HOLLOW MARINA NOB HILL SOUTH OF MARKET PACIFIC HEIGHTS JAPAN TOWN FILLMORE HAYES VALLEY CIVIC CENTER

SAN FRANCISCO

Parks Cable Car Lines Landmarks Points of Interest Neighborhoods Fairmont Hotel Fairmont Hotel 950 Mason St. San Francisco, CA 94108 (415) 772-5000 https://resweb.passkey.com/ go/osteoporosis

Mail to : UCSF Office of CME P.O. Box 45368

San Francisco, CA 94145-0368 Fax: (415) 502-1795

Registration Information: (415) 476-5808 Course Information: (415) 476-4251 Online registration: www.cme.ucsf.edu

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