Stem Cell Biology and Regenerative Medicine

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Stem Cell Biology and Regenerative Medicine

Series Editor

Kursad Turksen, Ph.D. kursadturksen@gmail.com

For further volumes:

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Tiziana A.L. Brevini

Editor

Stem Cells in Animal

Species: From Pre-clinic

to Biodiversity

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ISSN 2196-8985 ISSN 2196-8993 (electronic) ISBN 978-3-319-03571-0 ISBN 978-3-319-03572-7 (eBook) DOI 10.1007/978-3-319-03572-7

Springer Cham Heidelberg New York Dordrecht London Library of Congress Control Number: 2014940944

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The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specifi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.

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Printed on acid-free paper

Humana Press is a brand of Springer

Springer is part of Springer Science+Business Media (www.springer.com) Editor

Tiziana A.L. Brevini

Laboratory of Biomedical Embryology UniStem

Centre for Stem Cell Research Università degli Studi di Milano Milan , Italy

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v Part I Stem Cells for Pre-clinical Models

1 Stem Cells in Dystrophic Animal Models:

From Preclinical to Clinical Studies ... 3 Clemetina Sitzia, Silvia Erratico, Andrea Farini, Yvan Torrente,

and Mirella Meregalli

2 Understanding Tissue Repair Through the Activation

of Endogenous Resident Stem Cells ... 31 Iolanda Aquila, Carla Vicinanza, Mariangela Scalise,

Fabiola Marino, Christelle Correale, Michele Torella, Gianantonio Nappi, Ciro Indolfi , and Daniele Torella

3 Large Animal Induced Pluripotent Stem Cells

as Models of Human Diseases ... 49 Anjali Nandal and Bhanu Prakash V. L. Telugu

4 Fetal Adnexa-Derived Stem Cells Application

in Horse Model of Tendon Disease ... 69 Anna Lange-Consiglio and Fausto Cremonesi

Part II Stem Cells in “Non-conventional” Species 5 Using Stem Cells to Study and Preserve Biodiversity

in Endangered Big Cats ... 109

Rajneesh Verma and Paul John Verma

6 Pluripotent and Multipotent Domestic Cat Stem Cells:

Current Knowledge and Future Prospects ... 119

Martha C. Gómez and C. Earle Pope

Contributors

Iolanda Aquila Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences , Magna Graecia University , Catanzaro , Italy

Ida Biunno Institute for Genetic and Biomedical Research of the National Research Council (IRGB-CNR) , Milan , Italy

IRCCS Multimedica , Milan , Italy

Tiziana A. L. Brevini Laboratory of Biomedical Embryology, UniStem , Centre for Stem Cell Research, Università degli Studi di Milano , Milan , Italy

Christelle Correale Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences , Magna Graecia University , Catanzaro , Italy

Fausto Cremonesi Reproduction Unit , Large Animal Hospital, Università degli Studi di Milano, Polo Veterinario di Lodi , Lodi , Italy

Pasquale DeBlasio Integrated Systems Engineering SRL , Milan , Italy

Silvia Erratico Ystem SRL , Milan , Italy

Andrea Farini Stem Cell Laboratory, Department of Pathophysiology and Transplantation , Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari , Milan , Italy

Fulvio Gandolfi Laboratory of Biomedical Embryology, UniStem , Centre for Stem Cell Research, Università degli Studi di Milano , Milan , Italy

Martha C. Gómez Audubon Nature Institute Center for Research of Endangered Species , New Orleans , LA , USA

Ciro Indolfi Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences , Magna Graecia University , Catanzaro , Italy

Anna Lange-Consiglio Reproduction Unit , Large Animal Hospital, Università degli Studi di Milano, Polo Veterinario di Lodi , Lodi , Italy

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viii

Sara Maffei Laboratory of Biomedical Embryology, UniStem , Centre for Stem Cell Research, Università degli Studi di Milano , Milan , Italy

Fabiola Marino Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences , Magna Graecia University , Catanzaro , Italy

Mirella Meregalli Stem Cell Laboratory, Department of Pathophysiology and Transplantation , Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari , Milan , Italy

Ystem SRL , Milan , Italy

Anjali Nandal Department of Animal and Avian Sciences , University of Maryland , College Park , MD , USA

Animal Bioscience and Biotechnology Laboratory , USDA Agricultural Research Service (USDA-ARS) , Beltsville , MD , USA

Gianantonio Nappi Department of Cardio-Thoracic and Respiratory Sciences , Second University of Naples , Naples , Italy

C. Earle Pope Audubon Nature Institute Center for Research of Endangered Species , New Orleans , LA , USA

Mariangela Scalise Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences , Magna Graecia University , Catanzaro , Italy

Clemetina Sitzia Stem Cell Laboratory, Department of Pathophysiology and Transplantation , Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari , Milan , Italy

Bhanu Prakash V. L. Telugu Department of Animal and Avian Sciences , University of Maryland , College Park , MD , USA

Animal Bioscience and Biotechnology Laboratory , USDA Agricultural Research Service (USDA-ARS) , Beltsville , MD , USA

Michele Torella Department of Cardio-Thoracic and Respiratory Sciences , Second University of Naples , Naples , Italy

Daniele Torella Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy

Department of Cardio-Thoracic and Respiratory Sciences , Second University of Naples , Naples , Italy

Yvan Torrente Stem Cell Laboratory, Department of Pathophysiology and Transplantation , Università degli Studi di Milano, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Centro Dino Ferrari , Milan , Italy

Ystem SRL , Milan , Italy

Rajneesh Verma Monash Institute of Medical Research, Monash University, Melbourne, VIC, Australia

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ix Institute of Molecular Bioscience, Mahidol University, Bangkok, Thailand

Paul John Verma Stem Cells and Reprogramming Group, Biological Engineering Laboratories, Faculty of Engineering, Monash University, Melbourne, VIC, Australia South Australian Research and Development Institute (SARDI) , Adelaide , Australia Turretfi eld Research Centre, Rosedale, Australia

Carla Vicinanza Molecular and Cellular Cardiology, Department of Medical and Surgical Sciences , Magna Graecia University , Catanzaro , Italy

Stem Cell and Regenerative Biology Unit (BioStem) , Research Institute for Sport & Exercise Sciences (RISES), Liverpool John Moores University , Liverpool , UK Contributors

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xi

Dr. Tiziana A.L. Brevini is an Associate Professor of Anatomy and Embryology at

the University of Milan, Italy. She studied the interactions between the female geni-tal tract and the maturing oocyte in the Department of Molecular Embryology at the University of Cambridge, UK. She completed her doctorate degree in Endocrinology and Metabolic Sciences at the University of Milan, Italy, and then carried out research at Monash University in Melbourne, Australia, and at the University of Adelaide in Adelaide, Australia. Her main areas of research focus on the under-standing of cell differentiation and commitment, epigenetic control of cell fate, and pluripotency-related networks in mammalian cells and embryos.

Stem Cell Biology and Regenerative Medicine