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The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor initiating cells

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Figure

Figure 2Differentiation of Cul3-knockout hepatic progenitor cells leads to the induction of DNA damage and cellular senescence
Figure 3In vitro differentiation of progenitor cells recapitulates the in vivo phenotype
Figure 4Accumulation of cyclin E in differentiating hepatic progenitor cells is responsible for the accumulation of DNA damage
Figure 5Maintenance of senescence by p53 by immunofluorescence at the indi-cated time points after the induction of differentiation
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