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PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase

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Figure

Figure 1. Specific expression (of PYK2 in osteoclast-like cells in the coculture system
Figure 3. Cell adhesion or clustering of at 437�3 integrin induces tyrosine phosphorylation of PYK2 in prefusion osteoclast-like cells
Figure 4.  c-Src binds to PYK2 via the SH2 domain. (A) Co-immuno-precipitation of PYK2 and c-Src from OCLs
Figure 6. Adhesion-depen-dent translocation of PYK2 to the Triton-insoluble cytoskele-tal fraction in the prefusion os-teoclast-like cells
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