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The novel proteasome inhibitor carfilzomib activates and enhances extrinsic apoptosis involving stabilization of death receptor 5

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Academic year: 2020

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Figure

Figure 1: CFZ (A) effectively decreases the survival of cancer cells (B) and induces apoptosis (C and D) A, Chemical structure of CFZ
Figure 2: Caspase inhibition (A) caspase-8 knockdown (B) or FADD deficiency (C and D) protects cancer cells from CFZ-induced apoptosis
Figure 3: CFZ increases total (A and B) and cell surface (C) levels of DR5 and DR4 accompanied with elevated c-FLIP and Mcl-1 (D) A, B and D, The indicated cell lines were treated with the given concentrations of CFZ for 8 h (A and D) or with 100 nM CFZ fo
Figure 4: The combination of CFZ and TRAIL augments killing of cancer cells (A) with enhanced activation of caspases (B) A, The indicated cancer cell lines were treated with different concentrations of CFZ alone, TRAIL alone, and the combination of CFZ and
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