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Cohesin facilitates zygotic genome activation in zebrafish

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Figure

Fig. 1. Rad21 and CTCF are present pre-ZGA and can be effectivelydepleted in early zebrafish development.maternal transcripts are degraded and zygotic transcripts accumulate
Fig. 2. Rad21 depletion delays the onset ofthe zygotic transcription program. (A) PCAplot of RNA-seq triplicate samples for pools(n=100) of wild-type (WT), Rad21-depleted(KD) and CTCF-depleted (KD) conditions attime points 2.5-5.3 hpf
Fig. 3. Cohesin depletion delays expressionof zygotic genes.plot with means and 95% confidence intervals(three biological replicates per condition).Punpaired (A,B) Distribution ofsignificantly differentially representedtranscripts (FDR 0.05) in Rad21-deple
Fig. 4. Gene ontologies of differentially representedtranscripts in Rad21-depleted embryos
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