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Gli1 Transcriptional Activity is Negatively Regulated by AKT2 in Neuroblastoma

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Figure

Figure 1: PI3K/AKT2 pathway regulation of Gli1 transcriptional activity. (A) BE(2)-C and BE(2)-M17 cells expressing constitutively active form of PI3K subunit, p110α (pBabe-puro-PI3K-CA), decreased Gli1 transcriptional activity compared to cells transfecte
Figure 2: Anti-tumor function of Gli1 in neuroblastoma. (A) Gli1 overexpression inhibited neuroblastoma cell proliferation
Figure 3: AKT2 regulated Gli1 function by modulating its nuclear-cytoplasmic shuttling
Figure 4: AKT2 relieved GSK3β-mediated inhibition of SUFU and retained Gli1 in the cytoplasm of neuroblastoma cells

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