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Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

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Figure

Fig. 1 Cell line characterization and global analysis of DNA epigenetic modifications.gene in NSCs.by IF.polymerase chain reaction (qRT-PCR), normalized to DYNLL and expressed as the mean ± SEM.RNA (mRNA) expression.indicated onfcorrelation; a Representati
Fig. 2 GSC-specific transcriptomic profiles relative to NSCs.analysis of the top most commonly activated ( a Line plot showing the number of deregulation events shared among different GSClines
Fig. 3 Links between differentially modified enhancers and gene regulation events. a ChromHMM modeling of H3K27ac (top), H3K4me1 (middle),and co-marked regions (bottom) in GSCs and NSCs, and their co-localization with genomic features as labeled at the low
Fig. 4 Differential distribution of DNA marks between GSC and NSC. a Phyloepigenetic evolutionary tree demonstrating the progression andrelationship of the DNA methylation landscape from normal tissues/cell lines, to primary tumors, and GSCs isolated from
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