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INPP4B: the New Kid on the PI3K Block

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Figure

figure 1: INPP4b structure and function. A. Functional domains of INPP4B: C2 lipid binding domain amino acids 25-149, NHR domain amino acids 510-544, and putative Dual Phosphatase domain with the catalytic region C(X)5R
figure 2: regulation of the INPP4b expression. A. Interrogation of the AR and ER recruitment sites in the vicinity of the INPP4B locus
figure 3: INPP4b reduces Ar transcriptional activity. A. PC-3 cells were transfected for 24 hours with vector control, 50 or 100 ng INPP4B, and the androgen-responsive GRE-luciferase reporter construct
figure 4: INPP4b expression is not induced by testosterone in mice. C. To control for testosterone gene regulation, mice were treated with vehicle (V) (n=5) or 1 μg testosterone (T) (n=9)

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