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Protein Kinase D1 attenuates tumorigenesis in colon cancer by modulating β-catenin/T cell factor activity

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Figure

Figure 1: Expression of PKD1 is downregulated in colon cancer. (A)in colon tissues:cytoplasm and membrane of colon cells, while β-catenin was primarily localized to the membrane
Figure 2: PKD1 overexpression decreases tumorigenic phenotypes by inhibiting the nuclear transcriptional activity of β-catenin in SW480 colon cancer cells
Figure 3: Enzymatically active PKD1 is required for decreasing β-catenin co-transcription activity
Figure 4: PKD1 overexpression enhances membrane localization of β-catenin and decreases nuclear β-catenin transcription activity
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