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Doxycycline is an NF-κB inhibitor that induces apoptotic cell death in malignant T-cells

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Academic year: 2020

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Figure

Figure 1: Doxycycline decreases viability of a subset of CTCL cell lines. A-E. CTCL cell lines H9, MyLa, HH, Hut78, and MJ were cultured in the presence or absence of doxycycline (Dox) at the indicated concentrations
Figure 2: Doxycycline resistant cell lines are resistant to TNF-induced NF-κB pathway activation
Figure 3: Doxycycline pre-treatment prevents TNF induced phosphorylation of IκBα in doxycycline-sensitive CTCL cell lines
Figure 4: Doxycycline induces programmed cell death in sensitive CTCL cell lines. Doxycycline sensitive (H9, MyLa, HH, and Hut78) and insensitive (MJ) CTCL cell lines were either untreated or treated with the specified concentrations of Doxycycline (10μg/m
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