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Endothelial miR 30c suppresses tumor growth via inhibition of TGF β–induced Serpine1

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Academic year: 2020

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Figure

Figure 1. Postnatal deletion of Tgfbr2 in endothelium delays tumor growth and impairs blood vessel formation
Figure 2. Tgfbr2bar: 100 scale at bottom right indicates sprout depth in the 3D fibrin matrix
Figure 3. miR-30c mimics block Serpine1 expression and inhibit in vitro EC sprouting. (A) Two pathways to Serpine1 induction by TGF-β signaling in ECs
Figure 4. miR-30c gain of function in the endothelium inhibits tumor growth and reduces fibrin abundance, whereas miR-30c loss of function has the opposite effect
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