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Differential immune profiles distinguish the mutational subtypes of gastrointestinal stromal tumor

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Figure

Figure 1. ssGSEA identifies immune cell pathway enrichment in PDGFRA-mutant GIST. ssGSEA of 75 GIST specimens, organized by mutational driver and increasing ESTIMATE score
Figure 3. CIBERSORT and DGE analysis identify unique immune signatures in GIST. CIBERSORT (middle) and immune gene expression (bottom) of UPG KIT- and UPG PDGFRA-mutant GISTs, organized by mutational driver and increasing ESTIMATE score (n = 22)
Figure 4. PDGFRA- and KIT-mutant GISTs have distinct signaling and cytokine signatures
Figure 5. PDGFRA mutation produces multiple HLA-diverse, strong binding neoepitopes. (A) Pearson’s correlation of ESTIMATE (top) and CYT (bottom) scores with total neoepitope burden (left), number of high-affinity neoepitopes (middle), and number of very h
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