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Original Article MicroRNA-506 inhibits cell proliferation and invasion in prostate cancer by targeting HDAC4

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Academic year: 2020

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Figure

Figure 1. miR-506 expression is down-regulated in human PCa cell lines and tissues. A
Figure 2. Ectopic expression of miR-506 inhibits proliferation, blocks cell cycle progression and promotes apoptosis of DU145 and PC-3 cells
Figure 3. Ectopic expression of miR-506 suppresses cell migration and invasion. A. Migration of DU145 and PC-3 cells was determined by the wound healing assay
Figure 4. HDAC4 is a direct target of miR-506. (A) Schematic graph of the putative miR-506 target sequence in the wild-type HDAC4 3’-UTR (WT) and its mutant sequence containing altered nucleotides in the seeds sequence (MUT)

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