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MicroRNAs interfere with DNA methylation in rheumatoid arthritis synovial fibroblasts

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Figure

Figure 1(A) One-carbon cycle and polyamine metabolism regulate DNA methylation. (B) RASF showed decreased global DNAOASF vs control RASF, as well as between control RASF and RASF treated with L-methionine, n=6)
Figure 2(A and B) Changes in the levels of DNA methyltransferases (DNMTs) transcripts on treatment of RASF for 2 weeksDNMT3A, n=9); (C and D) linear regression lines with 95% CI, Spearmanwith 20 mM L-methionine (A) or betaine (B)
Figure 3Changes in microRNA expression on treatment of RASF for 2 weeks with 20 mM L-methionine or betaine
Figure 4(A and B) Pre-miR29/anti-miR29 and pre-let7f/anti-let7f did not affect the expression of DNMT1 transcripts
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