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Na+/Ca2+ antiport in the mammalian heart

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Figure

Fig. 1. Ionic homeostasis in cardiac myocytes. The transmembrane [Na+are maintained by the operation of the Namembrane Cahas an important effect on the force of cardiac contraction
Fig. 2. Orientation of the cardiac Na+/Ca2+ exchanger in the plasma membrane. This diagramis based on hydropathy analysis suggesting the presence of 11 transmembrane spanningsegments; the external orientation of the NH2 terminus of the protein is based on the presenceof an NH2-terminal cleaved signal sequence.
Fig. 3. Na+initiated by repetitive addition of 100mmoll-dependent inactivation of Na+/Ca2+ pig ventricular sarcolemmal patches is�1 NaCl to the cytoplasmic membrane surface.As indicated by the bar, 2mmoll�1 Mg2+–ATP was also applied for 110s during the sec
Fig. 4. Effect of ATP depletion (A) and cytochalasin D (Cyto D, B) on Na+glucamine and NaCl to generate the final Nacontrol cells, 10mmol ldescribed in A
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