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S100A4 drives non-small cell lung cancer invasion, associates with poor prognosis, and is effectively targeted by the FDA- approved anti-helminthic agent niclosamide

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Figure

Figure 1: S100A4 drives the invasive potential of lung cancer cells. A and B. Lung cancer cells as indicated were lysed in RIPA buffer, total cell lysates (80μg) were subjected to 15% SDS-PAGE, transferred and immunoblotted with rabbit anti-S100A4 antibody
Figure 2: S100A4 expression patterns in non-small cell lung carcinoma. (C), and strong (D) S100A4 expression in non-small cell lung cancers (left panels), with corresponding hematoxylin and eosin stained A-D
Table 1: Clinico-pathologic parameters and S100A4 expression in lung adenocarcinoma patients
Figure 4: Niclosamide decreases S100A4 expression, lung cancer cell proliferation, invasion and invasive growth
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