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Metabolic pathways regulated by TAp73 in response to oxidative stress

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Figure

Figure 1: Glutathione recycling is potentially greater in tAp73-/- versusthe cell. The availability of the amino acid precursor, cysteine, and the activity of the rate-limiting enzyme, glutamate cysteine ligase, are the key factors in GSH synthesis
Figure 2: loss of tAp73 enhances methionine metabolism following H2o2 treatment. Methionine is the initiating amino acid in the synthesis of eukaryotic proteins
Figure 3: Purine associated metabolites. a.-p. Levels of the indicated metabolites were evaluated as described in material and methods
Figure 4: Pyrimidine associated metabolites. a.methods. Anova contrasts -i. Levels of the indicated metabolites were evaluated as described in material and t-tests were used to identify biochemicals that differed significantly between experimental groups (n = 5 for each time point).
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