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STAT2 is a pervasive cytokine regulator due to its inhibition of STAT1 in multiple signaling pathways

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Figure

Fig 1. STAT2 binds STAT1 via high affinity N Domain interactions. (A) Stat2-deficient human U6A cells (S2-/-) and parental 2fTGH cells (WT) weremicrographs
Fig 3. STAT2 inhibits specifically STAT1 in response to both IL-27 and IL-6. (A) Western blot indicating the positions of latent(α) and activated (αp) STAT1α/β (S1α/β), STAT2 (S2), and STAT3 (S3)
Fig 5. Role of IRF9 and STAT2:STAT1 heterodimerization for gene induction by IFN-γ2fTGH cells (WT)2–3 independent experiments
Fig 7. STAT2 shifts the transcriptional output of IL-27 from STAT1 to STAT3. (A, B) Gene expressioncells and parental (S2-/-) and stably STAT2-reconstituted (S2 WT or S2 L82A) human U6A cells treated for 4 hwith 100 ng/ml IL-27.analyses using quantitative

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