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Why Transcription Factor Binding Sites Are Ten Nucleotides Long

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Figure

Figure 1 The lengths of binding sites range from 5 nt toto 2 bits (see�30 nt, in both eukaryotes (left, 454 curated transcriptionfactor motifs) and prokaryotes (right, 79 motifs)
Table 1 Parameters and range of empirical estimates for our population-genetic model of binding site evolution
Figure 2 The rate of deleterious mutations at a binding site can beof deleterious mutations that can occur at each nucleotide;ugives the degeneracy,occur at that nucleotide in a functional binding site, calculated from therelative frequency with which each
Figure 3 A simple population-Solid circles denote the stable re-gion determined by Monte Carlosimulations, and lines denote an-alyticaltions 4 and 5); arrows indicatethe direction of selection outsidemagnitude.values were derived from the lit-erature (Tabl
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