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The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

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Figure

Figure 1 Targets for cytotoxicity of nanoparticles (NPs).Notes: NPs may act through extracellular generation of reactive oxygen species (ROS) (1), they may physically damage the plasma membrane by causing holes (2) or bind to membrane proteins like nicotin
Figure 2 Simplified representation of active uptake mechanisms in nonphagocytic cells.Notes: Nanoparticle (•) uptake has been evaluated mainly according to macropinocytosis, represented here as only one route, through macropinosome (MP), clathrin-mediated
Table 2 Routes of endocytic uptake in nonphagocytic cells

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