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Effects of TI-299423 on Neuronal Nicotinic Acetylcholine Receptors

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Figure

Figure 1: Structure of compound TI-299423 and Nicotine.
Table 1: Affinity, Efficacy, and Potency of TI-299423 at α4β2*, α6β2*, and α3β4*-nAChRs
Figure 2: A) Concentration response of TI-299423 on α4-GFPβ2to-plasma concentration ratio increases over time, suggesting TI-299423 enters the brain from the plasma and ± 18.0 ng/ml at time 0.08 h
Figure 4: injected with saline (F0.01 mg/kg and 0.05 mg/kg (paired t-test, pre-injected with TI-299423 versus saline (Findividually significant at pre-injection doses 0.01 mg/kg and 0.05 mg/kg (paired t-test, presented are mean ± SEM.A) Rats (n=8) self-adm
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