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A conceptual framework for analyzing axial patterning in regenerating urodele limbs

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Figure

Fig. 1. Experimentsdemonstratingself-organizationof thelimbregenerationblastema.IAI Wrist blastemaof a rightforelimb(RFLJautograftedto themid-thighstumpof a righthindlimb(RHLJ.andviceversa.The graftedblastemas(black)differentiateaccordingto theirlimbtypean
Fig. 2. Cross-sectionof amputatedlimbillustratingcircumferential(shorterarrows)and centripetal(longerarrows)directionsof interca-lationto eliminatediscontinuitiesin the transverseplane.The dIrec-tions are deduced from the results of expenments on supernume
Fig. 3. RA-induced supernumerarylimbprobablyary" transverseformation.Left,11mb regener-ate of a urOdeletreatedwith100 ug RA/gmbodywt by intraperitonealinjectionduring the accumulationblastemastage.The limb was amputatedat the level of the wrist,but RA prox
Fig. 4. Affinophoresisassay for blastemajunctionassay.articulatearticulatescell affinity
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