Endogenous epidermal growth factor regulates the timing and pattern of embryonic mouse molar tooth morphogenesis

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$Fig. 3. Effectsof EGF onE16+4dcculturedmolars.EGF was adminis-teredto culturedmousemolarsat concentrationsof 2-20ng/mf.Theeffectson (AI rheamountofDNA synthesisand total DNA content,andlBItotal RNA and pro rein contentsweremeasured_E\ogenousEGF atconcentrationsof 10 and 15 ng/ml caused significant increases in all fourmeasuresof tooth morphogenesis.(*) Representsstatisticsignificance(p<O.05!.$

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