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The loss of gap junctional cell to cell communication is coupled with dedifferentiation of retinal pigmented epithelial cells in the course of transdifferentiation into the lens

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Academic year: 2020

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Figure

Fig. 1, Electronmicroscopicobservationof gap junctionsin culturedpigmentedepithelialcells(PECsl of the retina.(a) Low-powerview of anultrathin section cut verticallv to the plastic dish showsapico-basal polarityof PECs.J: junctional complex, 8M: basementme
Fig. 2. Electronmicroscopicobservationof dedifferentiatedPECs (dePECs).(a) Low-powerview of dePECs sectionedvertically to the plastic dish.R: ruffled membrane.(bl Junctional structuresare observedjust benearh the surface exposedto culture medium.They inclu
Fig. 3. ElectronmicroscopicJunctionsand pitsobservationof lentoidsformedby transdifferentiationof PECs
Fig. 5. Co-injectionof RITC-dextranand Lucifer Yellowinto PECs and lentoids.(a,d) Fluorescenceof RITe

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