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Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells

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Figure

Fig. 1 Hinge incorporation can promote the expansion of CAR T cells.independent experiments verified with cells from over three individual healthy human donors
Fig. 2 Hinge incorporation mainly promotes CD4+ CAR T cell expansion.analysis of the percentage of CD4+ and CD8+ PSCA-H.28z T (CD4+ T cell andhealthy human donors.when CD4+ T and CD8+ T cells were isolated and cultured them separately in vitro
Fig. 3 A hinge enhances the migratory capacity of CAR T cells. Cytotoxicity of (cells to transmigrate Matrigel
Fig. 4 19-H.28z T and 19.28z T cells have comparable antitumor efficacy in vivo. a Timeline and events of the experiment with intravenousNALM6-GL xenograft models
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