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Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells

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Figure

Figure 1 Hypoxia potentiated Notch1 signalling via stabilization and activation of transcription factor HIF-1Notch1 siRNA-transfected group; CS, control siRNA-transfected group
Figure 2 HIF-1independent experiments. (α and Notch1 expression are down-regulated in T-ALL cells transfected with specific siRNA
Figure 3 Hypoxia promotes proliferation of T-ALL cells by reducing the G0/G1 phase of the cell cycle
Figure 4 Hypoxia/HIF-1± SD of three separate experiments. (silenced compared with control
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