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Consequences of cell-to-cell P-glycoprotein transfer on acquired multidrug resistance in breast cancer: a cell population dynamics model

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Figure

Figure 1 Proliferation and resistance of MCF-7 variants in culturecounted every 12 hours in a Malassez chamber
Figure 2 Spatial organization of MCF-7 and MCF-7/Doxo in co-cultures. To obtain phase contrast micrographs of growing MCF-7 variants inco-cultures, dishes were seeded with a 50:50 mixture of MCF-7:MCF-7/Doxo at day 0
Figure 3 Flow cytometry analysis of P-gp and efflux activity transfers between MCF-7 and MCF-7/Doxo variants of the human breastcancer cell line
Figure 4 D-F, co-cultures obtained from 50:50 ctbMCF-7:MCF-7/Doxo, after 1 to 3 days. All analysiswere performed with unchanged excitation light power and photomultipliers voltage settings
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