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Regulation of Bim in Health and Disease

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Figure

Figure 1: The gene structure of Bim and its major isoform transcripts. A. Presentation of the Bim (Bcl-2L11) gene structure according to the nomenclature of U et al
Figure 2: Bim-induced apoptosis. Following exposure to a pro-apoptotic stimulus, a sudden intracellular rise in free activated Bim molecules (e.g., by increased transcription and/or translation, increased alternative splicing in favor of BimS, and/or relea
Figure 3: Bim at the cross-road between apoptosis and autophagy. In certain cell types such as epithelial and neuronal cells, BimEL and BimL are sequestered to the dynein motor complex through interaction with the dynein light chain DYNLL1
Figure 4: Transcriptional activation of Bim. Bim transcription can be upregulated by a whole range of transcription factors (outlined in green) whose activities are tightly regulated
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