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The within host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy

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Figure

Fig. 1 Characteristics of the study population. Our study was based on serial sputum isolates obtained from 12 TB patients at 2-week intervals.We obtained three sputum samples at each time point and cultured each on Löwenstein–Jenssen solid medium (L-J) or
Fig. 2 Sputum samples under-represent the true genetic diversity of MTBC populations in the lung
Fig. 3bselection. Alternatively, c a large number of physically separated populations each produce minor variants
Fig. 4 Allele dynamics in patients are congruent with purifying selection acting on MTBC populations treated with an efficacious drug combination.transition probability by re-sampling (N = 1000) the data with replacement
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