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PureCLIP: capturing target specific protein–RNA interaction footprints from single nucleotide CLIP seq data

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Figure

Fig. 1 Overview of the PureCLIP approach. a PureCLIP starts with mapped reads from a target iCLIP/eCLIP experiment and derives two signals: thepulled-down fragment density and individual read start counts
Fig. 2 Performance on simulated iCLIP-seq data. Precision vs number of true positive crosslink sites (top) and vs number of true positive bindingleftmost point of each curve corresponds to the number of true positives associated with the lowestreport
Fig. 3 Accuracy in detecting bona fide binding regions (depicted by gray areas). Left panel: a Distribution of the distances of the top 1000 sitescalled by each method to the closest PUM2 motif start position
Fig. 4 CL motif analysis of PUM2 eCLIP input data. Logo representation of the four top scoring motifs among the first 5000 PureCLIP crosslink sitescalled on the input dataset
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