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Why radiography should no longer be considered a surrogate outcome measure for longitudinal assessment of cartilage in knee osteoarthritis

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Figure

Figure 1. Radiographs at baseline and 2-year follow-up of a 61-year-old woman with osteoarthritis
Figure 2. Comparison of an anteroposterior radiograph and a coronal magnetic resonance image of the knee
Figure 3. Example of non-sensitivity of radiography. (a) Baseline coronal intermediate-weighted magnetic resonance imaging shows hyperintensity in the weight-bearing portion of the lateral tibial plateau but no defi nite cartilage defect
Figure 4. Example of non-sensitivity of radiography. (a) Baseline sagittal intermediate-weighted fat-suppressed image shows normal articular cartilage coverage in the medial femur and tibia
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