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Development and validation of a novel molecular biomarker diagnostic test for the early detection of sepsis

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Figure

Figure 1 A schematic of SeptiCyte lab development. Summaryof the development pathway of the SeptiCyte Lab test from highthroughput pre-clinical gene expression interrogation in an equinesepsis model through to clinical evaluation on a more dynamicplatform better suited to the assessment of smaller biomarkerpanels.
Figure 2 Composition of gene expression biomarkers in theSeptiCyte Lab test. Based on longitudinal sampling in pre-clinicaltrials using an equine sepsis model, molecular biomarkers related togenes directly involved in innate and early adaptive immunefunction, cell cycling, differentiation, extracellular remodelling, aswell as immune modulation.
Table 2 AUC ROC results comparing diagnosticperformance between control and various clinical cohorts
Figure 4 AUC ROC permutation comparisons and distribution graphs between mixed inflammation and Healthy Control cohortsA and B display results for the AUC ROC following 500 iterations using the full gene set and distribution results when cohort labels arer
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