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Nesprins and opposing microtubule motors generate a point force that drives directional nuclear motion in migrating neurons

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Academic year: 2020

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Figure

Fig. 1. The nucleus rotates in migrating GCGs. (A) Time-lapse sequences of a migrating CGC expressing GFP (green) and HP1and radial (bottom) migration in organotypic slices
Fig. 2. The nucleus rotates toward the direction of its translocation. (A) Nuclear translocation and rotation in a migrating CGC plotted against time
Fig. 3. Nesprin inhibition halts nuclear translocation androtation.displacements of nuclei during 5 h in CGCs expressing nesprinmutants.Trajectories of individual spots are shown on the right
Fig. 4. Inhibition of actin and of microtubules differentially affect nuclear movements
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