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MDA-9/Syntenin (SDCBP) modulates small GTPases RhoA and Cdc42 via transforming growth factor β1 to enhance epithelial- mesenchymal transition in breast cancer

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Figure

Figure 1: MDA-9 expression is elevated in breast cancer. a. Immunohistochemistry of breast cancer patient samples showing overexpression of MDA-9 in breast cancer
Figure 2: MDA-9 enhances invasion and cytoskeletal rearrangement. a. Western blots showing efficient silencing of MDA-9 in MDA-MB-231 cells, efficient silencing of MDA-9 in SUM159 cells and efficient over expression of MDA-9 in T47D cells
Figure 3: Silencing or overexpressing MDA-9 regulates EMT. a. Representative images showing change in morphology in 3D culture following silencing MDA-9 expression in MDA-MB-231 and SUM159 cells and overexpressing MDA-9 in T47D cells
Figure 4: MDA-9 modulates small GTPases RhoA and Cdc42 via TGFβ1. Fold change in active cdc42 and RhoA levels in a
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