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Optimization of the GluC1/IVM Neuronal Silencing Tool via Protein Engineering

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Figure

Figure 1-1.  Neuronal communication.  A. Typical neuron morphology consists of the cell body, dendrites, the axon, and presynaptic terminals
Figure 2-1.  Illustrated example of multiplexed orthogonal pharmacogenetics.  A. Two cell types (blue and orange) involved in a particular neural circuit (top) are genetically modified to express orthogonal actuators responding to several distinct ligands
Figure 2-2.  Mechanisms of orthogonal neuroreceptors.  GPCRs form the basis for both excitatory and inhibitory OP systems (A, D) based on interactions with different endogenous G proteins
Table 2-3.  Orthogonal neuroreceptors. Far-right columns indicate corresponding references
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