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A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias

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Figure

Figure 1Irf6 is a direct p63 target. (A) Microarray analysis of Irf6 RNA expression in mouse primary keratinocytes transfected with ΔNp63- or TAp63-specific siRNAs
Figure 2p63 is required for
Figure 3p63 mutations affect IRF6 expression in vitro and in vivo. (
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