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12/15 lipoxygenase–mediated enzymatic lipid oxidation regulates DC maturation and function

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Figure

Figure 1. BM-DCs express functionally active 12/15-LO. (mice and WT or A) Quantification of Alox15 mRNA expression levels in immature BM-DCs from WT and Alox15–/– mice or of Alox15 mRNA expression in WT BM-DCs after stimu-lation with LPS (100 ng/ml) for in
Figure 2. 12/15-LO regulates the maturation process of DCs. Flow cytometry–based analysis of (sion of the indicated surface molecules on human moDCs in the absence and presence of maturation (mat) cocktail
Figure 3. oxPC reverses the increased activation of 12/15-LO-deficient DCs. Flow cytometry–based analysis of the expression of MHC class II mole-cules and the indicated costimulatory molecules or activation markers on WT and Alox15 CD11c BM-DCs after LPS-induced maturation (100 ng LPS/
Figure 4. NRF2 mediates the immune-modulatory effects of 12/15-LO–derived oxidized phospholipids
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