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SDF1/CXCR4 signalling regulates two distinct processes of precerebellar neuronal migration and its depletion leads to abnormal pontine nuclei formation

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Fig. 2. CXCR4 expression in migrating PCN and SDF1 expressionin the meninges. Adjacent sections at various axial levels of mousehindbrains were subjected to in situ hybridisation for Mbh2(A,C,E,G,I,K) and Cxcr4 (B,D,F,H,J,L)
Fig. 3. PCN from LRL migrate preferentially towards co-culturedmeninges or recombinant SDF1 protein.quantification method
Fig. 4. PCN migration is markedly disrupted in Cxcr4where no from the LRL in the wild type (c, arrow), whereas in (d, arrow)
Fig. 5. Multiple posterior pontine clusters with bilaterally asymmetrical distribution are present in Cxcr4hindbrain showed bilaterally symmetrical PN anteriorly and LRN posteriorly (asterisks)
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