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A single base permutation in any loop of a folded intramolecular quadruplex influences its structure and stability

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Figure

Figure 1. A schematic representation of the folded structure for cles are syn-guanines, the red circles are thymidine and the blue circles are adenine
Figure 3. CD spectra of sequence variants with just one base different from the wild type, (TTAGGG)4, as a function of loop location: Wild Type (black); Loop 1 (red); Loop 2 (blue); Loop 3 (green)
Figure 4. CD optical melting profiles of all to 95loop variants: TTA (black circle); TAT (red square); ATT (green diamond); TTT (blue up triangle); AAT (pink down traingle); ATA (cyan star); TAA (dark red hexagon); AAA (dark green cross)
Figure 5. A comparison of the Tfrom the CD optical melting profiles: Loop 1 variants (black); Loop 2 variants (red) and Loop 3 variants (green)

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