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ALS associated missense and nonsense TBK1 mutations can both cause loss of kinase function

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Figure

Fig. 1. TBK1 mutations identi4IM0) mapping the mutations found in our study excluding premature stop codons and frameshift deletions
Table 1
Fig. 2. TBK1 p.G217R and p.R357X impair IRF3 phosphorylation as well as TBK1 binding with OPTN and its phosphorylation
Fig. 3. TBK1 p.G217R and p.R357X impair TBK1 phosphorylation and autophosphorylation and might reduce TBK1 homodimerization
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