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Notch RBP J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

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Figure 1. RBP-J controls expression of prototypical M1 genes(RbpjLysM-Cre (RBP-J-KO) and RbpjRbpjmonocytogenes strain 10403S and analyzed at day 3.5 post infection (n= 6 per group)
Figure 2. Induction of RBP-J-dependent M1 genes requires canonical Notch signaling(a) Quantitative PCR of IL12b mRNA expression in BMDMs from Rbpj+/+, Mx1-Cre (wild-type; WT) and Rbpjflox/flox, Mx1-Cre (RBP-J-KO) paired littermates, pretreated with the γ-s
Figure 3. RBP-J controls IRF8 expression and function(Mx1-Cre (RBP-J-KO) paired littermates, stimulated with LPS for the indicated periods.Mx1-Cre (WT) and RbpjLPS for the indicated periods
Figure 4. IRF8 mediates RBP-J-dependent activation of M1 gene expression(Irf8Cre (wild-type; WT) and Rbpja) Quantitative PCR of mRNA expression of the indicated genes in BMDMs from WT and−/− mice, stimulated with LPS for 3 h
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