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Bacterial drug tolerance under clinical conditions is governed by anaerobic adaptation but not anaerobic respiration

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Figure

FIG 1 Four-state switching model. (A) The extended four-state model with (i) normal aerobic cells that are susceptible to ciprofloxacin and ceftazidime killing(n), (ii) aerobic cells that are tolerant to ciprofloxacin only (p), (iii) anaerobic cells that are
Fig. S1E and F in the supplemental material). This shows that the
FIG 3 Functional classification of genes that are specifically induced and repressed in ceftazidime survivors and overlap hypoxia microarray data
FIG 4 Elimination of anaerobic survivors. (A) Validation of the predicted antibiotic susceptibilities of different anaerobic persister populations was assessed byadding a second antibiotic to wells with bacteria that were previously challenged for 24 h wit

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