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Ex vivo expansion of Hematopoietic Stem cells for Therapeutic purposes: Lessons from development and the niche

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Figure

Figure 1. Revised model for human HSC hierarchy. In the classic model for the human HSC hierarchy  LT-HSCs are defined by CD34+ CD38- CD45RA- CD90+CD49f+ which differentiates into MPPS,  CMPs, MLPs, GMPs
Figure 2. Regulation of HSCs maintenance in niche. Different cell types are involved in promoting  HSC maintenance, including perivascular stromal cells, endothelial cells (ECs), macrophages, CAR  cells, sympathetic neurons by producing cytokines and growt
Table 1. Summary of current protocols of ex vivo expansion of human HSCs.

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