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BACE-1 inhibition prevents the γ-secretase inhibitor evoked Aβ rise in human neuroblastoma SH-SY5Y cells

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Figure

Figure 1 Molecular structures of the inhibitorsstructure of the BACE inhibitor as described in Charrier et al., 2008[22].
Figure 2 APP expression and Ab secretion in SH-SY5Y cells. A. APP expression in non-transfected, APPwt- and APPswe-transfected SH-SY5Ycells
Figure 3 Effect of LY450139 on A(open circles), LY450139 produced a monophasic concentration-dependent inhibition of Ab secretion in SH-SY5Y cells.A
Figure 4 Washout experiments with LY450139 in SH-SY5Y cells(black bars). The media was replaced with fresh medium for another 24 h, and again collected for Abars).substrate accumulation.
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