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Repositioning drugs for traumatic brain injury - N-acetyl cysteine and Phenserine

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Figure

Fig. 1 a Structure N-acetyl cysteine. b Post injury administration of NAC (50 mg/kg daily for 4 days) significantly improves MWM performance.MWM performance as measured by latency to reach the goal platform was compared between groups: TBI, TBI-NAC, and Sh
Fig. 2 Number of clinical symptoms at seven days
Fig. 3 (−)-Phen is primarily metabolized by N-dethylation to yield (−)-N1- and (−)-N8-norphenserine that then are further N-dethylated to (−)-N1,N8-bisnorphenserine
Fig. 5 Cultured hippocampal neurons in triplicate were preparedfrom 18 to 20 day rat (Sprague Dawley) embryos and were culturedfor 7 days
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