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Preliminary in vitro and in vivo assessment of a new targeted inhibitor for choroidal neovascularization in age-related macular degeneration

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Academic year: 2020

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Figure

Figure 1 construction map of the plasmid pegFP-n2/cr2-sFlt 1.
Figure 2 cnV model (A–C) and therapeutic assessment of cr2-sFlt 1 (D).Notes: (A) ir fundus image of cnV mice induced by laser at the seventh day (green line is scan position of Figure [B], red arrows show laser spot)
Figure 3 chemotaxis of the gFP-labeled cr2-sFlt 1 toward complement cleavage fragments in the transwell assay (A–D) and mouse cnV model (E and F).Notes: (A) gFP signal of cr2-sFlt 1 suspension in the upper chamber before incubation
Figure 4 concentration analysis of VegF in the supernatant of the rPe cells treated with cr2-sFlt 1 (84 [A], 420 [B], and 840 μg/ml [C]) and bevacizumab (D).Notes: Data are expressed as mean ± standard deviation
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