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Regulation of liver mitochondrial metabolism during hibernation by post-translational modification

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Figure 1-1. Patterns of hibernation in the thirteen-lined ground squirrel. Core body temperature of a ground squirrel undergoing torpor-arousal cycles at the beginning of a hibernation season (A), and the metabolic rate and body temperature of a ground squ
Figure 1-2. The mammalian electron transport system (ETS). Electrons enter the ETS at complexes I and II following the oxidation of succinate and reducing equivalents NADH and FADH2
Figure 1-3. An example measurement of mitochondrial respiration in mitochondria isolated from the liver of a 13-lined ground squirrel
Figure 1-4. Succinate-fueled state 3 respiration rates in isolated liver mitochondria (measured at 37 °C) at six points of a torpor-IBE cycle
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Inducing metabolic suppression: the search for a “hibernation Immunoblots Isolation of Mitochondria Differences in liver mitochondrial proteins between torpor and Differences in ETS proteins in liver mitochondria between torpor Enzyme assays A model for mitochondrial metabolic suppression during torpor

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