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Metabolic and Target-Site Mechanisms Combine to Confer Strong DDT Resistance in Anopheles gambiae

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Figure

Table 1. GSTE2 allelic variants from the An. gambiae Kisumu and ZAN/U strain used for recombinant protein expression.
Figure 1. Comparison of GSTE2 catalysed DDT metabolism forthree variant recombinant proteins over a DDT dilution series.over a range of DDT concentrations and the mean production of DDEplotted from three replicate assays
Figure 2. Crystal structure of GSTE2fromKimusu 1B variant (grey; PDB entry IMI). A high degree of local and overall structural agreement is clearly noticeable
Figure 5. Geographical variation in frequency of Gste2represents the I114 and red the T114 frequency
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