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Update on the treatment of gastrointestinal stromal tumors (GISTs): role of imatinib

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Figure

Figure 1 Mechanism of action of imatinib.  A) Under physiological conditions,  ATP binds to KiT or PDGFrA, leading to phosphorylation and autoactivation of the receptor, or phosphorylation of substrate molecules resulting in activation of downstream signal
Table 1 response and clinical outcomes to pre-operative imatinib therapy: results of rTOG 0132/ACriN 6665 study
Figure 2 Structure of KiT and PDGFrA. The location and relative frequencies of GiST-associated kinase mutations are depicted in relation to the structural features of KiT Adapted with permission

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